The recent crystal structure of tetra nucleosomes supports zigzag-based models of chromatin fiber structure. The next challenge is to understand the modulation of chromatin structure in the nucleus, characterized by variability in DNA, histones and non-histone components.
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Woodcock, C. A milestone in the odyssey of higher-order chromatin structure. Nat Struct Mol Biol 12, 639–640 (2005). https://doi.org/10.1038/nsmb0805-639
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DOI: https://doi.org/10.1038/nsmb0805-639
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