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It takes a PHD to interpret histone methylation

Nature Structural & Molecular Biology volume 13, pages 572–574 (2006)Cite this article

Covalent modifications of histones play an important role in regulating chromatin structure and function, probably by serving as docking sites for effector proteins. The discovery that PHD fingers of two different proteins recognize trimethyl-Lys4 of histone H3 supports and extends this notion.

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Figure 1: Recognition of methylated lysines in H3.

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  1. the Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, 27599-7295, North Carolina, USA

    Yi Zhang

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Zhang, Y. It takes a PHD to interpret histone methylation. Nat Struct Mol Biol 13, 572–574 (2006). https://doi.org/10.1038/nsmb0706-572

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