Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNA allostery glimpsed

Nature Structural & Molecular Biology volume 13, pages 569–571 (2006)Cite this article

Riboswitches provide an elegantly simple means of coupling metabolic sensing to genetic regulation. Recent work provides a wealth of structural insight into ligand binding by these RNAs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genetic mechanisms of metabolite-sensing regulatory RNAs.
Figure 2: TPP- and SAM-sensing RNAs used in crystallography.
Figure 3: Common architecture for TPP switches.
Figure 4: Antiterminator sequestration in the TPP and SAM sensors.

References

  1. Nudler, E. & Mironov, A.S. Trends Biochem. Sci. 29, 11–17 (2004).

    Article  CAS  Google Scholar 

  2. Winkler, W.C. & Breaker, R.R. Annu. Rev. Microbiol. 59, 487–517 (2005).

    Article  CAS  Google Scholar 

  3. Jansen, J.A., McCarthy, T.J., Soukup, G.A. & Soukup, J.K. Nat. Struct. Mol. Biol. 13, 517–523 (2006).

    Article  CAS  Google Scholar 

  4. Montange, R.K. & Batey, R.T. Nature, advance online publication 28 Jun 2006 (doi:10.1038/nature04819).

  5. Serganov, A, Polonskaia, A, Phan, AT, Breaker, RR, Patel, DJ . Nature, advance online publication 21 May 2006 (doi:10.1038/nature04740).

  6. Thore, S., Leibundgut, M. & Ban, N. Science 312, 1208–1211 (2006).

    Article  CAS  Google Scholar 

  7. Vicens, Q. & Cech, T.R. Trends Biochem. Sci. 31, 41–51 (2006).

    Article  CAS  Google Scholar 

  8. Sudarsan, N., Cohen-Chalamish, S., Nakamura, S., Emilsson, G.M. & Breaker, R.R. Chem. Biol. 12, 1325–1335 (2005).

    Article  CAS  Google Scholar 

  9. Winkler, W.C., Nahvi, A. & Breaker, R.R. Nature 419, 952–956 (2002).

    Article  CAS  Google Scholar 

  10. McDaniel, B.A., Grundy, F.J. & Henkin, T.M. Mol. Microbiol. 57, 1008–1021 (2005).

    Article  CAS  Google Scholar 

  11. Gilbert, S.D., Stoddard, C.D., Wise, S.J. & Batey, R.T. J. Mol. Biol. 359, 754–768 (2006).

    Article  CAS  Google Scholar 

  12. Cromie, M.J., Shi, Y., Latifi, T. & Groisman, E.A. Cell 125, 71–84 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390-9038, Texas, USA

    Wade C Winkler & Charles E Dann III

Authors
  1. Wade C Winkler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles E Dann III
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Winkler, W., Dann, C. RNA allostery glimpsed. Nat Struct Mol Biol 13, 569–571 (2006). https://doi.org/10.1038/nsmb0706-569

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0706-569

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing