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Doughnuts dealing with RNA

The exosome is a complex composed of 3′→5′ exoribonucleases involved in RNA processing and degradation. The first high-resolution structure of the exosome core reveals a doughnut-like arrangement of six RNase PH–type subunits.

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Figure 1: Doughnut-shaped protein complexes involved in RNA metabolism.

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Acknowledgements

The author thanks R. Raijmakers for helpful suggestions and assistance in preparation of the figure and E. Conti, B. Prasad and K. Reinisch for kindly providing the coordinates of the complexes shown in the figure.

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Pruijn, G. Doughnuts dealing with RNA. Nat Struct Mol Biol 12, 562–564 (2005). https://doi.org/10.1038/nsmb0705-562

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