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Transcription meets DNA repair at a PH domain

Nature Structural & Molecular Biology volume 11, pages 588589 (2004) | Download Citation

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A recent study shows that the p62 subunit of the general transcription factor TFIIH contains a PH domain that interacts with a major component of the nucleotide excision repair (NER) machinery. The involvement of the PH domain in NER raises interesting questions regarding the dual role of TFIIH in transcription and DNA repair.

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Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. alexandre.akoulitchev@pathology.oxford.ac.uk

    • Kon Yew Kwek
    • , William O'Gorman
    •  & Alexandre Akoulitchev

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DOI

https://doi.org/10.1038/nsmb0704-588

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