A recent study shows that the p62 subunit of the general transcription factor TFIIH contains a PH domain that interacts with a major component of the nucleotide excision repair (NER) machinery. The involvement of the PH domain in NER raises interesting questions regarding the dual role of TFIIH in transcription and DNA repair.
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Kwek, K., O'Gorman, W. & Akoulitchev, A. Transcription meets DNA repair at a PH domain. Nat Struct Mol Biol 11, 588–589 (2004). https://doi.org/10.1038/nsmb0704-588
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DOI: https://doi.org/10.1038/nsmb0704-588
