Peptide bond formation by the ribosome is central to the expression of genetic information, yet its precise mechanism has resisted elucidation for decades. Two recent studies indicate that substrate orientation is the sole driving force behind the ribosome-catalyzed reaction.
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Gregory, S., Dahlberg, A. Peptide bond formation is all about proximity. Nat Struct Mol Biol 11, 586–587 (2004). https://doi.org/10.1038/nsmb0704-586
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DOI: https://doi.org/10.1038/nsmb0704-586
