News & Views | Published:

Peptide bond formation is all about proximity

Nature Structural & Molecular Biology volume 11, pages 586587 (2004) | Download Citation

Subjects

Peptide bond formation by the ribosome is central to the expression of genetic information, yet its precise mechanism has resisted elucidation for decades. Two recent studies indicate that substrate orientation is the sole driving force behind the ribosome-catalyzed reaction.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Accessions

References

  1. 1.

    , , & Cell 117, 589–599 (2004).

  2. 2.

    , , & Proc. Natl. Acad. Sci. USA 101, 7897–7901 (2004).

  3. 3.

    & Trends Biochem. Sci. 28, 411–418 (2003).

  4. 4.

    , , , & Science 289, 920–930 (2000).

  5. 5.

    , , & Nature 411, 498–501 (2001).

  6. 6.

    et al. Proc. Natl. Acad. Sci. USA 98, 9002–9007 (2001).

  7. 7.

    , , , & Mol. Cell 10, 1–20 (2002).

  8. 8.

    , & Nature 377, 309–314 (1995).

  9. 9.

    & Mol. Cell 4, 859–864 (1999).

  10. 10.

    , & Annu. Rev. Biochem. 72, 517–571 (2003).

  11. 11.

    & Proc. Natl. Acad. Sci. USA 98, 1393–1397 (2001).

  12. 12.

    , , & EMBO J. 20, 4214–4221 (2001).

Download references

Author information

Affiliations

  1. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA. Steven_Gregory@Brown.edu

    • Steven T Gregory
    •  & Albert E Dahlberg

Authors

  1. Search for Steven T Gregory in:

  2. Search for Albert E Dahlberg in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nsmb0704-586

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing