In this issue, Ishikawa and colleagues provide direct evidence to support the 'winch' hypothesis for the dynein motor mechanism, in which the AAA domain motor unit is displaced parallel to the doublet microtubule long axis rather than undergoing a rotary motion.
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Acknowledgements
The King laboratory is supported by grant GM51293 from the US National Institutes of Health.
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King, S. Axonemal dyneins winch the cilium. Nat Struct Mol Biol 17, 673–674 (2010). https://doi.org/10.1038/nsmb0610-673
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DOI: https://doi.org/10.1038/nsmb0610-673