Organisms possessing RNA-dependent RNA polymerase activity are known to produce endogenous small interfering RNAs (esiRNAs). It had been thought that organisms such as flies and mammals lacking this activity would not produce esiRNAs. However, it has now been shown that a functional esiRNA pathway is present in such animals; the esiRNAs are derived from a variety of endogenous double-stranded RNA substrates.
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Nilsen, T. Endo-siRNAs: yet another layer of complexity in RNA silencing. Nat Struct Mol Biol 15, 546–548 (2008). https://doi.org/10.1038/nsmb0608-546
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DOI: https://doi.org/10.1038/nsmb0608-546
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