Crystal structures of the Nipah and Hendra virus attachment protein complexed with ephrin-B2 shed light on the apparent paradox of ephrin-B2's flexibility for binding multiple receptors. Surprisingly, the switch from the use of glycan-based to protein-based receptors seems to have evolved independently from other protein-receptor–using paramyxoviruses such as the measles virus.
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Lee, B., Ataman, Z. & Jin, L. Evil versus 'eph-ective' use of ephrin-B2. Nat Struct Mol Biol 15, 540–542 (2008). https://doi.org/10.1038/nsmb0608-540
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DOI: https://doi.org/10.1038/nsmb0608-540
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PCalign: a method to quantify physicochemical similarity of protein-protein interfaces
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