Since the discovery that actin and actin-related proteins (ARPs) reside in the nucleus as integral subunits of chromatin-modifying and chromatin-remodeling complexes, efforts to uncover their roles in chromatin regulation have met with limited success. In a new study, the previously mysterious helicase-SANT–associated (HSA) domain found in many chromatin regulatory complexes is shown to act as a module that directs recruitment and contributes to the action of actin and ARPs in chromatin regulation.
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Gottschalk, A., Conaway, R. & Conaway, J. New clues to actin function in chromatin regulation. Nat Struct Mol Biol 15, 432–433 (2008). https://doi.org/10.1038/nsmb0508-432
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DOI: https://doi.org/10.1038/nsmb0508-432
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