Chromosomal breaks destabilize the genome and can cause developmental defects and diseases such as cancer. New work suggests that, shortly after DNA damage, dissociation of the histone binding protein HP1β from chromatin facilitates restoration of genome integrity.
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Acknowledgements
J.L. and J.B. are supported by grants from the Danish Cancer Society, the Danish National Research Foundation and the European Union (projects 'DNA repair' and 'GENICA'), and wish to thank C. Lukas and C. Dinant for critical comments on the manuscript.
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Lukas, J., Bartek, J. DNA damage: a histone-code mediator leaves the stage. Nat Struct Mol Biol 15, 430–432 (2008). https://doi.org/10.1038/nsmb0508-430
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DOI: https://doi.org/10.1038/nsmb0508-430
