Budding insights on cell polarity

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The yeast proteins Sro7 and Sro77, and their metazoan relatives Lgl and tomosyn, interact with plasma membrane SNARE proteins and control cell polarity. Recently, the crystal structure of yeast Sro7 has been solved, yielding fascinating insights and even more unanswered questions concerning the molecular mechanism of these proteins.

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Figure 1: Schematic overview of the Sro7 and the tomosyn SNARE complex structures.

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Fasshauer, D., Jahn, R. Budding insights on cell polarity. Nat Struct Mol Biol 14, 360–362 (2007) doi:10.1038/nsmb0507-360

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