A major challenge in gene expression is to understand how precursor messenger RNA (pre-mRNA) processing events are integrated with transcription. A recent study suggests that distant exons in nascent RNA are held together during transcription, promoting accurate splicing independent of intron fate.
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References
Dye, M.J., Gromak, N. & Proudfoot, N.J. Mol. Cell 21, 849–859 (2006).
Black, D.L. Annu. Rev. Biochem. 72, 291–336 (2003).
Konforti, B.B. & Konarska, M.M. RNA 1, 815–827 (1995).
Bruzik, J.P. & Maniatis, T. Proc. Natl. Acad. Sci. USA 92, 7056–7059 (1995).
Osheim, Y.N., Miller, O.L. Jr & Beyer, A.L. Cell 43, 143–151 (1985).
Wetterberg, I., Zhao, J., Masich, S., Wieslander, L. & Skoglund, U. EMBO J. 20, 2564–2574 (2001).
Visa, N., Izaurralde, E., Ferreira, J., Daneholt, B. & Mattaj, I.W. J. Cell Biol. 133, 5–14 (1996).
Eperon, L.P., Graham, I.R., Griffiths, A.D. & Eperon, I.C. Cell 54, 393–401 (1988).
Dreyfuss, G., Kim, V.N. & Kataoka, N. Nat. Rev. Mol. Cell Biol. 3, 195–205 (2002).
Stark, J.M., Bazett-Jones, D.P., Herfort, M. & Roth, M.B. Proc. Natl. Acad. Sci. USA 95, 2163–2168 (1998).
Wetterberg, I., Bauren, G. & Wieslander, L. RNA 2, 641–651 (1996).
de la Mata, M. et al. Mol. Cell 12, 525–532 (2003).
Batsche, E., Yaniv, M. & Muchardt, C. Nat. Struct. Mol. Biol. 13, 22–29 (2006).
Kornblihtt, A.R. Nat. Struct. Mol. Biol. 13, 5–7 (2006).
Fededa, J.P. et al. Mol. Cell 19, 393–404 (2005).
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Neugebauer, K. Please hold—the next available exon will be right with you. Nat Struct Mol Biol 13, 385–386 (2006). https://doi.org/10.1038/nsmb0506-385
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DOI: https://doi.org/10.1038/nsmb0506-385
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