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Please hold—the next available exon will be right with you

A major challenge in gene expression is to understand how precursor messenger RNA (pre-mRNA) processing events are integrated with transcription. A recent study suggests that distant exons in nascent RNA are held together during transcription, promoting accurate splicing independent of intron fate.

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Figure 1: Pre-mRNA continuity in splicing.

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Neugebauer, K. Please hold—the next available exon will be right with you. Nat Struct Mol Biol 13, 385–386 (2006). https://doi.org/10.1038/nsmb0506-385

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