La sets the tone for telomerase assembly

The functional assembly of a ciliate telomerase requires ordered RNA conformational changes mediated by a La motif–containing protein. This raises new questions about telomerase biogenesis and the evolutionary origin of the telomerase RNA.

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Figure 1: p65-assisted telomerase RNA folding steps, according to ref.4.
Figure 2: Apparently distinct biogenesis pathways for telomerase RNAs in evolutionarily distant eukaryotes.

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Teixeira, M., Gilson, E. La sets the tone for telomerase assembly. Nat Struct Mol Biol 14, 261–262 (2007). https://doi.org/10.1038/nsmb0407-261

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