A new study reports the hUpf2-hUpf3b interaction domain structure and provides the first structural insight into the core of the nonsense-mediated decay pathway. Surprisingly, the RNA-recognition motif of hUpf3b, a domain typically involved in RNA binding, constitutes instead an interaction surface for hUpf2.
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Lykke-Andersen, J. Making structural sense of nonsense-mediated decay. Nat Struct Mol Biol 11, 305–306 (2004). https://doi.org/10.1038/nsmb0404-305
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DOI: https://doi.org/10.1038/nsmb0404-305
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