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Glutamate receptor ion channels: where do all the calories go?

Nature Structural & Molecular Biology volume 18, pages 253254 (2011) | Download Citation

Glutamate receptor ion channels use the free energy of ligand binding to trigger ion channel activation and desensitization. In this issue, an analysis of all-atom molecular dynamics simulations dissects the binding process, reveals a substantial gain in free energy produced by domain closure for agonists and reports unique energy landscapes for individual ligands.

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Author information

Affiliations

  1. Mark L. Mayer is at the Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

    • Mark L Mayer

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The author declares no competing financial interests.

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Correspondence to Mark L Mayer.

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DOI

https://doi.org/10.1038/nsmb0311-253

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