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Glutamate receptor ion channels: where do all the calories go?

Nature Structural & Molecular Biology volume 18, pages 253–254 (2011)Cite this article

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Glutamate receptor ion channels use the free energy of ligand binding to trigger ion channel activation and desensitization. In this issue, an analysis of all-atom molecular dynamics simulations dissects the binding process, reveals a substantial gain in free energy produced by domain closure for agonists and reports unique energy landscapes for individual ligands.

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Figure 1: Free-energy changes revealed by molecular dynamics simulations for the GluA2 LBD.

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Authors and Affiliations

  1. Mark L. Mayer is at the Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.,

    Mark L Mayer

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  1. Mark L Mayer
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Correspondence to Mark L Mayer.

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The author declares no competing financial interests.

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Mayer, M. Glutamate receptor ion channels: where do all the calories go?. Nat Struct Mol Biol 18, 253–254 (2011). https://doi.org/10.1038/nsmb0311-253

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