Glutamate receptor ion channels use the free energy of ligand binding to trigger ion channel activation and desensitization. In this issue, an analysis of all-atom molecular dynamics simulations dissects the binding process, reveals a substantial gain in free energy produced by domain closure for agonists and reports unique energy landscapes for individual ligands.
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Mayer, M. Glutamate receptor ion channels: where do all the calories go?. Nat Struct Mol Biol 18, 253–254 (2011). https://doi.org/10.1038/nsmb0311-253
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DOI: https://doi.org/10.1038/nsmb0311-253