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Closing the circle on ribonucleotide reductases

Nature Structural & Molecular Biology volume 18, pages 251–253 (2011)Cite this article

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In this issue, a wide array of structural and biochemical techniques are applied to reveal the molecular details of activity regulation in one of life's most essential enzymes, the ribonucleotide reductase.

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Figure 1: The three different classes of RNR6,7,11,20,21.
Figure 2: Schematic overview of the two modes of allosteric regulation in ribonucleotide reductases.
Figure 3: Different architectures of inactive RNR complexes.

References

  1. Reichard, P. Biochem. Biophys. Res. Commun. 396, 19–23 (2010).

    Article  CAS  Google Scholar 

  2. Nordlund, P. & Reichard, P. Annu. Rev. Biochem. 75, 681–706 (2006).

    Article  CAS  Google Scholar 

  3. Fairman, J.W. et al. Nat. Struct. Mol. Biol. 18, 316–322 (2011).

    Article  CAS  Google Scholar 

  4. Eklund, H., Uhlin, U., Färnegårdh, M., Logan, D.T. & Nordlund, P. Prog. Biophys. Mol. Biol. 77, 177–268 (2001).

    Article  CAS  Google Scholar 

  5. Larsson, K.M., Logan, D.T. & Nordlund, P. ACS Chem. Biol. 5, 933–942 (2010).

    Article  CAS  Google Scholar 

  6. Uhlin, U. & Eklund, H. Nature 370, 533–539 (1994).

    Article  CAS  Google Scholar 

  7. Nordlund, P., Sjöberg, B.-M. & Eklund, H. Nature 345, 593–598 (1990).

    Article  CAS  Google Scholar 

  8. Uppsten, M., Färnegårdh, M., Domkin, V. & Uhlin, U. J. Mol. Biol. 359, 365–377 (2006).

    Article  CAS  Google Scholar 

  9. Eriksson, M. et al. Structure 5, 1077–1092 (1997).

    Article  CAS  Google Scholar 

  10. Larsson, K.-M., Andersson, J., Sjöberg, B.-M., Nordlund, P. & Logan, D.T. Structure 9, 739–750 (2001).

    Article  CAS  Google Scholar 

  11. Larsson, K.M. et al. Nat. Struct. Mol. Biol. 11, 1142–1149 (2004).

    Article  CAS  Google Scholar 

  12. Xu, H. et al. Proc. Natl. Acad. Sci. USA 103, 4022–4027 (2006).

    Article  CAS  Google Scholar 

  13. Kashlan, O.B., Scott, C.P., Lear, J.D. & Cooperman, B.S. Biochemistry 41, 462–474 (2002).

    Article  CAS  Google Scholar 

  14. Cooperman, B.S. & Kashlan, O.B. Adv. Enzyme Regul. 43, 167–182 (2003).

    Article  CAS  Google Scholar 

  15. Wang, J., Lohman, G.J. & Stubbe, J. Proc. Natl. Acad. Sci. USA 104, 14324–14329 (2007).

    Article  CAS  Google Scholar 

  16. Rofougaran, R., Vodnala, M. & Hofer, A. J. Biol. Chem. 281, 27705–27711 (2006).

    Article  CAS  Google Scholar 

  17. Rofougaran, R., Crona, M., Vodnala, M., Sjöberg, B.-M. & Hofer, A. J. Biol. Chem. 283, 35310–35318 (2008).

    Article  CAS  Google Scholar 

  18. Torrents, E., Eliasson, R., Wolpher, H., Gräslund, A. & Reichard, P. J. Biol. Chem. 276, 33488–33494 (2001).

    Article  CAS  Google Scholar 

  19. Brown, N.C. & Reichard, P. J. Mol. Biol. 46, 39–55 (1969).

    Article  CAS  Google Scholar 

  20. Logan, D.T., Andersson, J., Sjöberg, B.-M. & Nordlund, P. Science 283, 1499–1504 (1999).

    Article  CAS  Google Scholar 

  21. Sintchak, M.D., Arjara, G., Kellogg, B.A., Stubbe, J. & Drennan, C.L. Nat. Struct. Biol. 9, 293–300 (2002).

    Article  CAS  Google Scholar 

  22. Crona, M. Ph.D. thesis, Stockholm University (2010).

  23. Torrents, E., Westman, M., Sahlin, M. & Sjöberg, B.M. J. Biol. Chem. 281, 25287–25296 (2006).

    Article  CAS  Google Scholar 

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Acknowledgements

The author thanks Anders Liljas for help with Figure 2.

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  1. Derek T. Logan is in the Department of Biochemistry and Structural Biology at Lund University, Lund, Sweden.,

    Derek T Logan

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Correspondence to Derek T Logan.

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Logan, D. Closing the circle on ribonucleotide reductases. Nat Struct Mol Biol 18, 251–253 (2011). https://doi.org/10.1038/nsmb0311-251

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