Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A common means to an end

Analyses of telomere-binding proteins show structural and functional conservation with subunits of replication protein A, the canonical single-stranded DNA–binding protein. These studies raise intriguing questions about the structure and general role of DNA binding in telomere length homeostasis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: OB folds of RPA and Cdc13.

References

  1. Smogorzewska, A. & de Lange, T. Annu. Rev. Biochem. 73, 177–208 (2004).

    Article  CAS  Google Scholar 

  2. Gao, H., Cervantes, R.B., Mandell, E.K., Otero, J.H. & Lundblad, V. Nat. Struct. Mol. Biol. 14, 208–214 (2007).

    Article  CAS  Google Scholar 

  3. Wold, M.S. Annu. Rev. Biochem. 66, 61–92 (1997).

    Article  CAS  Google Scholar 

  4. Croy, J.E. & Wuttke, D.S. Trends Biochem. Sci. 31, 516–525 (2006).

    Article  CAS  Google Scholar 

  5. Grandin, N., Reed, S.I. & Charbonneau, M. Genes Dev. 11, 512–527 (1997).

    Article  CAS  Google Scholar 

  6. Grandin, N., Damon, C. & Charbonneau, M. EMBO J. 20, 1173–1183 (2001).

    Article  CAS  Google Scholar 

  7. Petreaca, R.C. et al. Nat. Cell Biol. 8, 748–755 (2006).

    Article  CAS  Google Scholar 

  8. Pennock, E., Buckley, K. & Lundblad, V. Cell 104, 387–396 (2001).

    Article  CAS  Google Scholar 

  9. Smith, J., Zou, H. & Rothstein, R. Biochimie 82, 71–78 (2000).

    Article  CAS  Google Scholar 

  10. Schramke, V. et al. Nat. Genet. 36, 46–54 (2004).

    Article  CAS  Google Scholar 

  11. Salas, T.R. et al. Nucleic Acids Res. 34, 4857–4865 (2006).

    Article  CAS  Google Scholar 

  12. Philipova, D., Mullen, J.R., Maniar, H.S., Gu, C. & Brill, S.J. Genes Dev. 10, 2222–2233 (1996).

    Article  CAS  Google Scholar 

  13. Saeki, H. et al. Proc. Natl. Acad. Sci. USA 103, 8768–8773 (2006).

    Article  CAS  Google Scholar 

  14. Fanning, E., Klimovich, V. & Nager, A.R. Nucleic Acids Res. 34, 4126–4137 (2006).

    Article  CAS  Google Scholar 

  15. Zubko, M.K. & Lydall, D. Nat. Cell Biol. 8, 734–740 (2006).

    Article  CAS  Google Scholar 

  16. Henson, J.D., Neumann, A.A., Yeager, T.R. & Reddel, R.R. Oncogene 21, 598–610 (2002).

    Article  CAS  Google Scholar 

  17. Larrivee, M. & Wellinger, R.J. Nat. Cell Biol. 8, 741–747 (2006).

    Article  CAS  Google Scholar 

  18. Bochkarev, A., Pfuetzner, R.A., Edwards, A.M. & Frappier, L. Nature 385, 176–181 (1997).

    Article  CAS  Google Scholar 

  19. Bochkareva, E., Korolev, S., Lees-Miller, S.P. & Bochkarev, A. EMBO J. 21, 1855–1863 (2002).

    Article  CAS  Google Scholar 

  20. Mitton-Fry, R.M., Anderson, E.M., Theobald, D.L., Glustrom, L.W. & Wuttke, D.S. J. Mol. Biol. 338, 241–255 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haring, S., Wold, M. A common means to an end. Nat Struct Mol Biol 14, 176–177 (2007). https://doi.org/10.1038/nsmb0307-176

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0307-176

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing