tRNA genes as chromatin barriers

Chromatin barriers restrict silenced chromatin domains from invading active domains. A recent study shows that a tRNA gene functions as a barrier in Schizosaccharomyces pombe. These results, similar to previous observations in Saccharomyces cerevisiae, point toward a novel function for tRNA genes and a common mechanism of compartmentalizing and organizing eukaryotic chromatin.

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Figure 1: Schematic representation of S. pombe centromere.

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Haldar, D., Kamakaka, R. tRNA genes as chromatin barriers. Nat Struct Mol Biol 13, 192–193 (2006). https://doi.org/10.1038/nsmb0306-192

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