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tRNA genes as chromatin barriers

Nature Structural & Molecular Biology volume 13, pages 192–193 (2006)Cite this article

Chromatin barriers restrict silenced chromatin domains from invading active domains. A recent study shows that a tRNA gene functions as a barrier in Schizosaccharomyces pombe. These results, similar to previous observations in Saccharomyces cerevisiae, point toward a novel function for tRNA genes and a common mechanism of compartmentalizing and organizing eukaryotic chromatin.

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Figure 1: Schematic representation of S. pombe centromere.

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Authors and Affiliations

  1. the Unit on Chromatin and Transcription, National Institute of Child Health and Human Development, US National Institutes of Health, 18 Library Dr., Bethesda, 20892, Maryland, USA

    Devyani Haldar

  2. the Department of MCD Biology, University of California, 249 Sinsheimer Labs, 1156 High Street, Santa Cruz, 95064, California, USA

    Rohinton T Kamakaka

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  1. Devyani Haldar
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  2. Rohinton T Kamakaka
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Haldar, D., Kamakaka, R. tRNA genes as chromatin barriers. Nat Struct Mol Biol 13, 192–193 (2006). https://doi.org/10.1038/nsmb0306-192

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