Recent structures of Dicer and the related bacterial enzyme, RNase III, demonstrate how Dicer acts as a molecular ruler, measuring out a precise length of double stranded RNA before cleavage.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Macrae, I.J. et al. Science 311, 195–198 (2006).
Gan, J. et al. Cell 124, 355–366 (2006).
Sun, W., Pertzev, A. & Nicholson, A.W. Nucleic Acids Res. 33, 807–815 (2005).
Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. Nat. Struct. Mol. Biol. 11, 576–577 (2004).
Ma, J.B., Ye, K. & Patel, D.J. Nature 429, 318–322 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cook, A., Conti, E. Dicer measures up. Nat Struct Mol Biol 13, 190–192 (2006). https://doi.org/10.1038/nsmb0306-190
Issue Date:
DOI: https://doi.org/10.1038/nsmb0306-190