Although RecA filaments are required for genetic recombination, it now seems that they are not required for translesion synthesis and that they actually inhibit this process. This finding along with elegant biochemical studies of mutant proteins moves us closer to discerning the direct role of RecA protein in SOS mutagenesis.
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References
Witkin, E.M. Bacteriol Rev. 40, 869–907 (1976).
Radman, M. In Molecular and Environmental Aspects of Mutagenesis (eds. Prakash, L., Sherman, F., Miller, M., Lawrence, C. & Tabor, H.W.) 128–142 (Charles C. Thomas, Springfield, Illinois, USA, 1974).
Courcelle, J., Khodursky, A., Peter, B., Brown, P.O. & Hanawalt, P.C. Genetics 158, 41–64 (2001).
Freidberg, E.C., Walker, G.C. & Siede, W. DNA Repair and Mutagenesis (American Society for Microbiology, Washington, DC, 1995).
Burckhardt, S.E., Woodgate, R., Scheuermann, R.H. & Echols, H. Proc. Natl. Acad. Sci. USA 86, 1811–1815 (1988).
Tang, M. et al. Proc. Natl. Acad. Sci. USA 96, 8919–8924 (1999).
Reuven, N.B., Arad, G., Maor-Shoshani, A. & Livneh, Z. J. Biol. Chem. 274, 31763–31766 (1999).
Kato, T. & Shinoura, Y. Mol. Gen. Genet. 156, 121–131 (1977).
Nohmi, T., Battista, J.R., Dodson, L.A. & Walker, G.C. Proc. Natl. Acad. Sci. USA 85, 1816–1820 (1988).
Sweasy, J.B., Witkin, E.M., Sinha, N., Roegner-Maniscalco, V. J. Bacteriol. 172, 3030–3036 (1990).
Dutreix, M. et al. J. Bacteriol. 171, 2415–2423 (1989).
Yang, W. Curr. Opin. Struct. Biol. 13, 23–30 (2003).
Witkin, E.M., McCall, J.O., Volkert, M.R. & Wermundsen, I.E. Mol. Gen. Genet. 185, 43–50 (1982).
Schlacher, K. et al. Mol. Cell 17, 561–572 (2005).
Cox, M.M. Annu. Rev. Microbiol. 57, 551–577 (2003).
Harmon, F.G., Rehrauer, W.M. & Kowalczykowski, S.C. J. Biol. Chem. 271, 23874–23883 (1996).
Acknowledgements
This paper is dedicated to the memory of Hatch Echols. I wish to thank S. Wallace, D. DiMaio, L. Loeb and M. Camps for helpful suggestions.
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Sweasy, J. RecA kicks Pol V into gear. Nat Struct Mol Biol 12, 215–216 (2005). https://doi.org/10.1038/nsmb0305-215
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DOI: https://doi.org/10.1038/nsmb0305-215
