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A seminal study of soluble adenylyl cyclase

Nature Structural & Molecular Biology volume 12, pages 7–8 (2005)Cite this article

In mammals, a soluble bicarbonate-regulated adenylyl cyclase is required for sperm fertility. Crystal structures of a cyanobacterial cousin provide new insights into the molecular mechanisms of activation and catalysis in soluble adenylyl cyclase and other class III nucleotidyl cyclases.

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Figure 1: Atomic structures and conformational changes of S. platensis and Gαs-bound transmembrane adenylyl cyclases.

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  1. University of Texas at Austin, Austin, 78712-0165, Texas, USA

    John J G Tesmer

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  1. John J G Tesmer
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Tesmer, J. A seminal study of soluble adenylyl cyclase. Nat Struct Mol Biol 12, 7–8 (2005). https://doi.org/10.1038/nsmb0105-7

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