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Arrest of CFTRΔF508 folding

Nature Structural & Molecular Biology volume 12, pages 2–3 (2005)Cite this article

The deletion of residue 508 in CFTR is the most common cystic fibrosis–causing mutation. Recent studies indicate that the main chain and side chain of this residue contribute to the proper folding of CFTR at different stages.

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Figure 1: Domain structure of CFTR.
Figure 2: Misfolding and selection of CFTRΔF508 for degradation.

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Acknowledgements

Research in the laboratory of D.M.C. is supported by the US National Institutes of Health and Cystic Fibrosis Foundation.

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  1. Department of Cell and Developmental Biology and the North Carolina Cystic Fibrosis Research Center, The University of North Carolina, Chapel Hill, 27599, North Carolina, USA

    Douglas M Cyr

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  1. Douglas M Cyr
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Cyr, D. Arrest of CFTRΔF508 folding. Nat Struct Mol Biol 12, 2–3 (2005). https://doi.org/10.1038/nsmb0105-2

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