Sculpting a domain by splicing

A recent study demonstrates that a short insert from alternative splicing in a common protein domain leads to rearrangements of surface loops and domain fold. The results provide a structural basis for the change of functional properties associated with alternative splicing.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: β-strand takeover by an alternatively spliced sequence.

References

  1. 1

    Maniatis, T. & Tasic, B. Nature 418, 236–243 (2002).

    CAS  Article  Google Scholar 

  2. 2

    Jimenez, J.L. et al. J. Mol. Biol. 333, 621–639 (2003).

    CAS  Article  Google Scholar 

  3. 3

    Sutton, R.B., Davletov, B.A., Berghuis, A.M., Sudhof, T.C. & Sprang, S.R. Cell 80, 929–938 (1995).

    CAS  Article  Google Scholar 

  4. 4

    Essen, L.O., Perisic, O., Lynch, D.E., Katan, M. & Williams, R.L. Biochemistry 36, 2753–2762 (1997).

    CAS  Article  Google Scholar 

  5. 5

    Garcia, J., Gerber, S.H., Sugita, S., Sudhof, T.C. & Rizo, J. Nat. Struct. Mol. Biol. 11, 45–53 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Fenster, S.D. et al. Neuron 25, 203–214 (2000).

    CAS  Article  Google Scholar 

  7. 7

    Wang, X. et al. J. Cell Biol. 147, 151–162 (1999).

    CAS  Article  Google Scholar 

  8. 8

    Fenster, S.D. & Garner, C.C. Int. J. Dev. Neurosci. 20, 161–171 (2002).

    CAS  Article  Google Scholar 

  9. 9

    Kriventseva, E.V. et al. Trends Genet. 19, 124–128 (2003).

    CAS  Article  Google Scholar 

  10. 10

    Shao, X., Davletov, B.A., Sutton, R.B., Sudhof, T.C. & Rizo, J. Science 273, 248–251 (1996).

    CAS  Article  Google Scholar 

  11. 11

    von Poser, C., Ichtchenko, K., Shao, X., Rizo, J. & Sudhof, T.C. J. Biol. Chem. 272, 14314–14319 (1997).

    CAS  Article  Google Scholar 

  12. 12

    Gerber, S.H., Garcia, J., Rizo, J. & Sudhof, T.C. EMBO J. 20, 1605–1619 (2001).

    CAS  Article  Google Scholar 

  13. 13

    Rudenko, G., Nguyen, T., Chelliah, Y., Sudhof, T.C. & Deisenhofer, J. Cell 99, 93–101 (1999).

    CAS  Article  Google Scholar 

  14. 14

    Peneff, C. et al. EMBO J. 20, 6191–6202 (2001).

    CAS  Article  Google Scholar 

  15. 15

    Grabowski, P.J. & Black, D.L. Prog. Neurobiol. 65, 289–308 (2001).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank J. Rizo for providing the atomic coordinates of the long C2A prior to publication.

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Davletov, B., Jiménez, J. Sculpting a domain by splicing. Nat Struct Mol Biol 11, 4–5 (2004). https://doi.org/10.1038/nsmb0104-4

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing