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Poly(A) tails: longer is not always better

Deadenylation of mRNAs is generally associated with translational inhibition and mRNA decay. A study now reports that, unexpectedly, highly expressed genes tend to have shorter poly(A) tails and suggests that poly(A) tails can be 'pruned', generating a 30-nucleotide-biased phased distribution, likely due to protection by poly(A)-binding proteins.

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Figure 1: Phasing of poly(A) tails likely generated by the interaction with PABPs may influence translation efficiency of mRNAs.


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Correspondence to Ariel A Bazzini.

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Castellano, L., Bazzini, A. Poly(A) tails: longer is not always better. Nat Struct Mol Biol 24, 1010–1011 (2017).

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