Chromatin remodelers are ATP-driven enzymes that can slide nucleosomes along DNA. Chen and colleagues present a tantalizing ∼4-Å view of the SWI/SNF ATPase motor bound to the nucleosome, which offers novel structural clues into the remodeling process.
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Acknowledgements
The authors acknowledge support from the Wellcome Trust and Cancer Research UK (D.B.W.) and the US National Institutes of Health (R01GM-084192 to G.D.B.).
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Wigley, D., Bowman, G. A glimpse into chromatin remodeling. Nat Struct Mol Biol 24, 498–500 (2017). https://doi.org/10.1038/nsmb.3415
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DOI: https://doi.org/10.1038/nsmb.3415