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Carb cutting works better with a partner

O-GlcNAc is a reversible post-translational modification that is added by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA). OGA is emerging as a therapeutic target for multiple diseases, but its structure has been elusive until now.

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Figure 1: Regulation of the O-GlcNAc post-translational modification.
Figure 2: Structure of OGA.
Figure 3: Inhibition of OGA.

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Acknowledgements

The author acknowledges support from the NIH for related projects in her lab (R21DK112733).

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Correspondence to Jennifer J Kohler.

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Kohler, J. Carb cutting works better with a partner. Nat Struct Mol Biol 24, 433–435 (2017). https://doi.org/10.1038/nsmb.3405

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