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CFTR structure: lassoing cystic fibrosis


Loss of function of the CFTR anion channel leads to cystic fibrosis, the most common inherited condition in humans of European origin. A recently reported structure for CFTR at 3.7-Å resolution reveals an unexpected 'lasso' domain and provides new insights into channel function in healthy individuals and in people with cystic fibrosis.

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Figure 1: Zebrafish CFTR structure determined by Zhang and Chen3 using cryo-electron microscopy.


  1. Riordan, J.R. et al. Science 245, 1066–1073 (1989).

    Article  CAS  Google Scholar 

  2. Van Goor, F. et al. Proc. Natl. Acad. Sci. USA 106, 18825–18830 (2009).

    Article  CAS  Google Scholar 

  3. Zhang, Z. & Chen, J. Cell 167, 1586–1597 (2016).

    Article  CAS  Google Scholar 

  4. Bozoky, Z. et al. Proc. Natl. Acad. Sci. USA 110, E4427–E4436 (2013).

    Article  CAS  Google Scholar 

  5. Aleksandrov, A.A. et al. J. Mol. Biol. 419, 41–60 (2012).

    Article  CAS  Google Scholar 

  6. Gee, H.Y., Tang, B.L., Kim, K.H. & Lee, M.G. J. Biol. Chem. 285, 35519–35527 (2010).

    Article  CAS  Google Scholar 

  7. Eckford, P.D., Li, C., Ramjeesingh, M. & Bear, C.E. J. Biol. Chem. 287, 36639–36649 (2012).

    Article  CAS  Google Scholar 

  8. Sheppard, D.N. & Welsh, M.J. Physiol. Rev. 79, S23–S45 (1999).

    Article  CAS  Google Scholar 

  9. Van Goor, F. et al. Pediatr. Pulmonol. 44, 154–155 (2009).

    Google Scholar 

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Correspondence to Bob Ford.

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Competing interests

B.F. consulted in 2015 and 2016 for Vertex, Inc., which discovered and currently markets ivacaftor.

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Ford, B. CFTR structure: lassoing cystic fibrosis. Nat Struct Mol Biol 24, 13–14 (2017).

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