A conserved long noncoding RNA expressed at the 5S rDNA ribosomal locus has acquired a novel function in alternative-splicing regulation in primates, owing to the insertion of a mobile Alu element. This discovery opens new perspectives regarding the roles of transposable elements in expanding the human transcriptome and may be applied as a biotechnology tool to drive gene-specific changes in alternative splicing.
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Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease
Chromosome Research Open Access 19 February 2018
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Luco, R. Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA. Nat Struct Mol Biol 23, 952–954 (2016). https://doi.org/10.1038/nsmb.3318
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DOI: https://doi.org/10.1038/nsmb.3318
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Warning SINEs: Alu elements, evolution of the human brain, and the spectrum of neurological disease
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