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The membrane strikes back: phosphoinositide binding regulates Skywalker function

Nature Structural & Molecular Biology volume 23, pages 956957 (2016) | Download Citation

Drosophila Skywalker regulates the GTPase Rab35, thereby controlling the turnover of synaptic-vesicle proteins. A new crystal structure of the TBC domain of Skywalker reveals an unexpected phosphoinositide-binding pocket, which is critical for synaptic function and is disrupted in DOORS syndrome–causing mutations in the human Skywalker homolog TBC1D24.

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Author information

Affiliations

  1. Steven J. Del Signore and Avital A. Rodal are at the Department of Biology, Brandeis University, Waltham, Massachusetts, USA.

    • Steven J Del Signore
    •  & Avital A Rodal

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Avital A Rodal.

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DOI

https://doi.org/10.1038/nsmb.3313

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