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A timer to coordinate substrate processing by the 26S proteasome

Nature Structural & Molecular Biology volume 22, pages 652–653 (2015)Cite this article

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The eukaryotic 26S proteasome is responsible for degrading virtually any protein with an appropriate ubiquitin signal, and in the process ubiquitin is spared and recycled. Two studies of the proteasome-associated deubiquitinase UBP6 now shed light on how deubiquitination coordinates the cycle of substrate processing.

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Figure 1: Deubiquitination by RPN11 and UBP6 coordinates the cycle of substrate processing.

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  1. Tingting Yao is at the Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA.,

    Tingting Yao

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  1. Tingting Yao
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Correspondence to Tingting Yao.

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Yao, T. A timer to coordinate substrate processing by the 26S proteasome. Nat Struct Mol Biol 22, 652–653 (2015). https://doi.org/10.1038/nsmb.3085

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