Grab the wiggly tail: new insights into the dynamics of circadian clocks

How do molecular interactions determine the period length of a circadian oscillator? In mammals, a disordered region of the BMAL1 transcription factor that is able to interact with activators or repressors seems to perform this function.

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Figure 1: Model of the mammalian circadian oscillator.
Figure 2: Analysis of the differences between BMAL1 and BMAL2.

Marina Corral Spence/Nature Publishing Group

Figure 3: Properties of disordered proteins may explain differences in the function of BMAL1 and BMAL2.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Jürgen A Ripperger.

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Hui, K., Ripperger, J. Grab the wiggly tail: new insights into the dynamics of circadian clocks. Nat Struct Mol Biol 22, 435–436 (2015). https://doi.org/10.1038/nsmb.3039

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