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Light-driven Na+ pumps as next-generation inhibitory optogenetic tools

Nature Structural & Molecular Biology volume 22, pages 351–353 (2015)Cite this article

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The first structures of a light-driven sodium pump provide insight into the mechanism of ion transport and selectivity. Genetic manipulation of rat neuronal cells and of Caenorhabditis elegans worms demonstrates the utility of such pumps for optogenetic applications.

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Figure 1: Retinal-binding proteins used as optogenetic tools.
Figure 2: Kr2 cavities as part of the ion-translocation pathway.

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Authors and Affiliations

  1. Przemyslaw Nogly and Jörg Standfuss are at the Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland.,

    Przemyslaw Nogly & Jörg Standfuss

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  1. Przemyslaw Nogly
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  2. Jörg Standfuss
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Correspondence to Jörg Standfuss.

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The authors declare no competing financial interests.

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Nogly, P., Standfuss, J. Light-driven Na+ pumps as next-generation inhibitory optogenetic tools. Nat Struct Mol Biol 22, 351–353 (2015). https://doi.org/10.1038/nsmb.3017

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