Methylation gets into rhythm with NAD+-SIRT1

Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.

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Figure 1: Dynamic cross-talk between cellular energy metabolism and chromatin regulation controls circadian rhythmicity of gene expression.

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Correspondence to Katrin F Chua.

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Tasselli, L., Chua, K. Methylation gets into rhythm with NAD+-SIRT1. Nat Struct Mol Biol 22, 275–277 (2015). https://doi.org/10.1038/nsmb.3004

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