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SET-ting the stage for DNA repair

Nature Structural & Molecular Biology volume 21, pages 655–657 (2014)Cite this article

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Mechanisms of DNA damage repair within actively transcribed genes are poorly understood. Five new reports shed light on the contributions of chromatin to this process by uncovering roles for histone H3 Lys36 methylation, a post-translational modification previously linked to transcription elongation, in the control of DNA-damage signaling and double strand break repair.

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Figure 1: H3K36 methylation functions in DSB sensing and repair.

References

  1. Hoeijmakers, J.H. N. Engl. J. Med. 361, 1475–1485 (2009).

    Article  CAS  Google Scholar 

  2. Polo, S.E. & Jackson, S.P. Genes Dev. 25, 409–433 (2011).

    Article  CAS  Google Scholar 

  3. Chapman, J.R., Taylor, M.R. & Boulton, S.J. Mol. Cell 47, 497–510 (2012).

    Article  CAS  Google Scholar 

  4. Papamichos-Chronakis, M. & Peterson, C.L. Nat. Rev. Genet. 14, 62–75 (2013).

    Article  CAS  Google Scholar 

  5. Venkatesh, S. & Workman, J.L. Wiley Interdiscip. Rev. Dev. Biol. 2, 685–700 (2013).

    Article  CAS  Google Scholar 

  6. Fnu, S. et al. Proc. Natl. Acad. Sci. USA 108, 540–545 (2011).

    Article  CAS  Google Scholar 

  7. Luco, R.F. et al. Science 327, 996–1000 (2010).

    Article  CAS  Google Scholar 

  8. Li, F. et al. Cell 153, 590–600 (2013).

    Article  CAS  Google Scholar 

  9. Aymard, F. et al. Nat. Struct. Mol. Biol. 21, 366–374 (2014).

    Article  CAS  Google Scholar 

  10. Carvalho, S. et al. eLife 3, e02482 (2014).

    Article  Google Scholar 

  11. Jha, D.K. & Strahl, B.D. Nat. Commun. 5, 3965 (2014).

    Article  CAS  Google Scholar 

  12. Pai, C.C. et al. Nat. Commun. 5, 4091 (2014).

    Article  CAS  Google Scholar 

  13. Pfister, S.X. et al. Cell Reports 7, 2006–2018 (2014).

    Article  CAS  Google Scholar 

  14. Kim, H.S., Rhee, D.K. & Jang, Y.K. Biochem. Biophys. Res. Commun. 368, 419–425 (2008).

    Article  CAS  Google Scholar 

  15. Symington, L.S. & Gautier, J. Annu. Rev. Genet. 45, 247–271 (2011).

    Article  CAS  Google Scholar 

  16. Lawrence, M.S. et al. Nature 505, 495–501 (2014).

    Article  CAS  Google Scholar 

  17. Putnam, C.D. et al. Proc. Natl. Acad. Sci. USA 109, E3251–E3259 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Deepak K. Jha and Brian D. Strahl are at the Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, North Carolina, USA.,

    Deepak K Jha & Brian D Strahl

  2. Brian D. Strahl is also at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA.,

    Brian D Strahl

  3. Department of Oncology, Sophia X. Pfister and Timothy C. Humphrey are at the Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.,

    Sophia X Pfister & Timothy C Humphrey

Authors
  1. Deepak K Jha
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  2. Sophia X Pfister
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  3. Timothy C Humphrey
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  4. Brian D Strahl
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Correspondence to Timothy C Humphrey or Brian D Strahl.

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Jha, D., Pfister, S., Humphrey, T. et al. SET-ting the stage for DNA repair. Nat Struct Mol Biol 21, 655–657 (2014). https://doi.org/10.1038/nsmb.2866

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