Grb-ing receptor activation by the tail

Hyperactivation of receptor tyrosine kinase pathways is a common theme in cancer. The recent demonstration that an imbalance between the fibroblast growth factor receptor 2–binding proteins Grb2 and phospholipase C-γ1 can lead to invasive behavior in the absence of growth factors highlights an emerging concept in cellular-signaling homeostasis.

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Figure 1: Alternative mechanisms of PLCγ1 activation downstream of FGFR2.

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Correspondence to Richard P Grose.

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Fearon, A., Grose, R. Grb-ing receptor activation by the tail. Nat Struct Mol Biol 21, 113–114 (2014). https://doi.org/10.1038/nsmb.2767

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