Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Conformational dynamics of STIM1 activation

Nature Structural & Molecular Biology volume 20, pages918–919(2013)Cite this article

Subjects

An Erratum to this article was published on 04 October 2013

This article has been updated

The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear. A study in this issue provides important new insights into the conformational changes that occur during STIM1 activation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

Figure 1: Model of the structural dynamics underlying STIM1 activation and ORAI channel gating.

Change history

  • 23 August 2013

    In the version of this article initially published, "Lys251" was incorrectly substituted for "Leu251" in Figure 1 and in the text. The error has been corrected in the HTML and PDF versions of the article.

References

  1. 1

    Hogan, P.G., Lewis, R.S. & Rao, A. Annu. Rev. Immunol. 28, 491–533 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Shaw, P.J., Qu, B., Hoth, M. & Feske, S. Cell. Mol. Life Sci. 70, 2637–2656 (2005).

    Article  Google Scholar 

  3. 3

    Liou, J. et al. Curr. Biol. 15, 1235–1241 (2005).

    CAS  Article  Google Scholar 

  4. 4

    Roos, J. et al. J. Cell Biol. 169, 435–445 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Stathopulos, P.B., Zheng, L., Li, G.Y., Plevin, M.J. & Ikura, M. Cell 135, 110–122 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Stathopulos, P.B., Li, G.Y., Plevin, M.J., Ames, J.B. & Ikura, M. J. Biol. Chem. 281, 35855–35862 (2006).

    CAS  Article  Google Scholar 

  7. 7

    Luik, R.M., Wang, B., Prakriya, M., Wu, M.M. & Lewis, R.S. Nature 454, 538–542 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Luik, R.M., Wu, M.M., Buchanan, J. & Lewis, R.S. J. Cell Biol. 174, 815–825 (2006).

    CAS  Article  Google Scholar 

  9. 9

    Baba, Y. et al. Proc. Natl. Acad. Sci. USA 103, 16704–16709 (2006).

    CAS  Article  Google Scholar 

  10. 10

    Covington, E.D., Wu, M.M. & Lewis, R.S. Mol. Biol. Cell 21, 1897–1907 (2010).

    CAS  Article  Google Scholar 

  11. 11

    Park, C.Y. et al. Cell 136, 876–890 (2009).

    CAS  Article  Google Scholar 

  12. 12

    Yuan, J.P. et al. Nat. Cell Biol. 11, 337–343 (2009).

    CAS  Article  Google Scholar 

  13. 13

    Kawasaki, T., Lange, I. & Feske, S. Biochem. Biophys. Res. Commun. 385, 49–54 (2009).

    CAS  Article  Google Scholar 

  14. 14

    Muik, M. et al. J. Biol. Chem. 284, 8421–8426 (2009).

    CAS  Article  Google Scholar 

  15. 15

    Yang, X., Jin, H., Cai, X., Li, S. & Shen, Y. Proc. Natl. Acad. Sci. USA 109, 5657–5662 (2012).

    CAS  Article  Google Scholar 

  16. 16

    Zhou, Y, et al. Nat. Struct. Mol. Biol. 20, 973–981 (2013).

    CAS  Article  Google Scholar 

  17. 17

    Várnai, P., Toth, B., Toth, D.J., Hunyady, L. & Balla, T. J. Biol. Chem. 282, 29678–29690 (2007).

    Article  Google Scholar 

  18. 18

    Wu, M.M., Buchanan, J., Luik, R.M. & Lewis, R.S. J. Cell Biol. 174, 803–813 (2006).

    CAS  Article  Google Scholar 

  19. 19

    Korzeniowski, M.K., Manjarres, I.M., Varnai, P. & Balla, T. Sci. Signal. 3, ra82 (2010).

    CAS  Article  Google Scholar 

  20. 20

    Muik, M. et al. EMBO J. 30, 1678–1689 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. Stefan Feske is at the Department of Pathology, New York University School of Medicine, New York, New York, USA.

    Stefan Feske

  2. Murali Prakriya is at the Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, Chicago, Illinois, USA.

    Murali Prakriya

Authors
  1. Stefan Feske
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Murali Prakriya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefan Feske.

Ethics declarations

Competing interests

Stefan Feske is a scientific cofounder and consultant of Calcimedica. Murali Prakriya declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Feske, S., Prakriya, M. Conformational dynamics of STIM1 activation. Nat Struct Mol Biol 20, 918–919 (2013). https://doi.org/10.1038/nsmb.2647

Download citation

Further reading

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing