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Conformational dynamics of STIM1 activation

An Erratum to this article was published on 04 October 2013

This article has been updated

The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear. A study in this issue provides important new insights into the conformational changes that occur during STIM1 activation.

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Figure 1: Model of the structural dynamics underlying STIM1 activation and ORAI channel gating.

Change history

  • 23 August 2013

    In the version of this article initially published, "Lys251" was incorrectly substituted for "Leu251" in Figure 1 and in the text. The error has been corrected in the HTML and PDF versions of the article.

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Correspondence to Stefan Feske.

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Stefan Feske is a scientific cofounder and consultant of Calcimedica. Murali Prakriya declares no competing financial interests.

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Feske, S., Prakriya, M. Conformational dynamics of STIM1 activation. Nat Struct Mol Biol 20, 918–919 (2013). https://doi.org/10.1038/nsmb.2647

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