A newly uncovered activity of a family of Polycomb-group proteins provides insight into the mechanisms by which active genes become repressed during the transition from pluripotency to restricted cell fates as stem cells undergo lineage specification.
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Change history
20 December 2012
In the version of this article initially published, the first author's name in ref. 3 was given as 'Brein'; the correct spelling is 'Brien'. The error has been corrected in the HTML and PDF versions of the article.
References
Ballaré, C. et al. Nat. Struct. Mol. Biol. 19, 1257–1265 (2012).
Musselman, A. et al. Nat. Struct. Mol. Biol. 19, 1266–1272 (2012).
Brien, G. et al. Nat. Struct. Mol. Biol. 19, 1273–1281 (2012).
Landeira, D. & Fisher, A.G. Trends Cell Biol. 21, 74–80 (2011).
Simon, J.A. & Kingston, R.E. Nat. Rev. Mol. Cell Biol. 10, 697–708 (2009).
Cao, R. et al. Mol. Cell. Biol. 28, 1862–1872 (2008).
Sarma, K. et al. Mol. Cell. Biol. 28, 2718–2731 (2008).
Nekrasov, M. et al. EMBO J. 26, 4078–4088 (2007).
Savla, U. et al. Development 135, 813–817 (2008).
Casanova, M. et al. Development 138, 1471–1482 (2011).
Pasini, D. et al. Mol. Cell. Biol. 27, 3769–3779 (2007).
Pek, J.W. et al. Development 139, 2255–2266 (2012).
Yuan, W. et al. J. Biol. Chem. 286, 7983–7989 (2011).
Schmitges, F.W. et al. Mol. Cell 42, 330–341 (2011).
Sánchez, C. et al. Mol. Cell. Proteomics 6, 820–834 (2007).
Pasini, D. et al. Genes Dev. 22, 1345–1355 (2008).
Schmitz, S.U. et al. EMBO J. 30, 4586–4600 (2011).
Ficz, G. et al. Development 132, 3963–3976 (2005).
Vissers, J.H. et al. J. Cell Sci. 125, 3939–3948 (2012).
Hong, Z. et al. Nucleic Acids Res. 36, 2939–2947 (2008).
Friberg, A. et al. Protein Sci. 19, 1906–1916 (2010).
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Abed, J., Jones, R. H3K36me3 key to Polycomb-mediated gene silencing in lineage specification. Nat Struct Mol Biol 19, 1214–1215 (2012). https://doi.org/10.1038/nsmb.2458
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DOI: https://doi.org/10.1038/nsmb.2458
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