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Solving the mystery of procollagen chain selectivity

Nature Structural & Molecular Biology volume 19, pages 977978 (2012) | Download Citation

The recently solved crystal structure of the procollagen C propeptide reveals the basis for chain selectivity as well as an unexpected asymmetry to this homotrimeric molecule. In addition, mapping disease-causing mutations to the structure demonstrates clear correlation between severity of disease and mutation location.

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Author information

Affiliations

  1. Neil J. Bulleid is at the Institute of Cellular, Molecular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

    • Neil J Bulleid

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The author declares no competing financial interests.

Corresponding author

Correspondence to Neil J Bulleid.

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DOI

https://doi.org/10.1038/nsmb.2397

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