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PICking apart Pol II initiation

Nature Structural & Molecular Biology volume 19, pages 737–738 (2012)Cite this article

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The recent mapping and modeling of protein-protein interfaces between general transcription factors TFIIE, TFIIH and Pol II have provided new insights into TFIIH-mediated melting of the transcription start site to form an open Pol II preinitiation complex and the stabilization of the complex by TFIIE, leading to a new mechanistic model for open-complex formation.

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Figure 1: Structural perspective on the stepwise assembly pathway.

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Authors and Affiliations

  1. Michael Carey is at the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.,

    Michael Carey

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  1. Michael Carey
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Correspondence to Michael Carey.

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The author declares no competing financial interests.

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Carey, M. PICking apart Pol II initiation. Nat Struct Mol Biol 19, 737–738 (2012). https://doi.org/10.1038/nsmb.2349

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