Dynein dynamics

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Abstract

Dyneins are the largest of the cytoskeletal motor proteins, and their mechanochemical behavior is complex. Recent high-resolution crystallographic structures have revealed new surprises regarding motor domain organization and new insights into how force and movement are achieved.

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Figure 1: Structural organization of the dynein motor.

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Acknowledgements

The authors are supported by US National Institutes of Health grant GM47434 (to R.B.V.). We thank S. Weil for critical reading of this manuscript.

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Correspondence to Richard Vallee.

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The authors declare no competing financial interests.

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