Structural studies of the epidermal growth factor receptor (EGFR) have advanced greatly in recent years, but they have used a 'divide-and-conquer' approach for independent study of the intracellular and extracellular regions. Several recent papers provide important new perspectives on 'undivided' EGFR and describe the initial steps in reconstructing signaling behavior of the intact receptor.
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References
Ullrich, A. & Schlessinger, J. Cell 61, 203–212 (1990).
Endres, N.F., Engel, K., Das, R., Kovacs, E. & Kuriyan, J. Curr. Opin. Struct. Biol. 21, 777–784 (2011).
Lemmon, M.A. & Schlessinger, J. Cell 141, 1117–1134 (2010).
Burgess, A.W. et al. Mol. Cell 12, 541–552 (2003).
Zhang, X., Gureasko, J., Shen, K., Cole, P.A. & Kuriyan, J. Cell 125, 1137–1149 (2006).
Macdonald, J.L. & Pike, L.J. Proc. Natl. Acad. Sci. USA 105, 112–117 (2008).
Alvarado, D., Klein, D.E. & Lemmon, M.A. Cell 142, 568–579 (2010).
Low-Nam, S.T. et al. Nat. Struct. Mol. Biol. 18, 1244–1249 (2011).
Mi, L.Z. et al. Nat. Struct. Mol. Biol. 18, 984–989 (2011).
Wang, Z. et al. Nat. Struct. Mol. Biol. 18, 1388–1393 (2011).
Qiu, C. et al. Biochemistry 48, 6624–6632 (2009).
Mi, L.Z. et al. Biochemistry 47, 10314–10323 (2008).
Sharma, S.V., Bell, D.W., Settleman, J. & Haber, D.A. Nat. Rev. Cancer 7, 169–181 (2007).
Li, S. et al. Cancer Cell 7, 301–311 (2005).
Zhang, X. et al. Nature 450, 741–744 (2007).
Lu, C. et al. Mol. Cell. Biol. 30, 5432–5443 (2010).
Wood, E.R. et al. Cancer Res. 64, 6652–6659 (2004).
Adak, S., Yang, K.S., Macdonald-Obermann, J. & Pike, L.J. J. Biol. Chem. published online, 10.1074/jbc.M111.274175 (8 November 2011).
Lynch, T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Sengupta, P. et al. Biophys. J. 96, 4887–4895 (2009).
Tynan, C.J. et al. Mol. Cell. Biol. 31, 2241–2252 (2011).
Red Brewer, M. et al. Mol. Cell 34, 641–651 (2009).
Tieleman, D.P. & Berendsen, H.J.C. J. Chem. Phys. 105, 4871–4880 (1996).
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Bessman, N., Lemmon, M. Finding the missing links in EGFR. Nat Struct Mol Biol 19, 1–3 (2012). https://doi.org/10.1038/nsmb.2221
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DOI: https://doi.org/10.1038/nsmb.2221
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