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Finding the missing links in EGFR

Nature Structural & Molecular Biology volume 19, pages 13 (2012) | Download Citation

Structural studies of the epidermal growth factor receptor (EGFR) have advanced greatly in recent years, but they have used a 'divide-and-conquer' approach for independent study of the intracellular and extracellular regions. Several recent papers provide important new perspectives on 'undivided' EGFR and describe the initial steps in reconstructing signaling behavior of the intact receptor.

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Affiliations

  1. Nicholas J. Bessman and Mark A. Lemmon are both in the Department of Biochemistry and Biophysics and in the Graduate Group in Biochemistry and Molecular Biophysics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Nicholas J Bessman
    •  & Mark A Lemmon

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  1. Search for Nicholas J Bessman in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Mark A Lemmon.

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DOI

https://doi.org/10.1038/nsmb.2221

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