Commentary | Published:

Prospects for an HIV vaccine: leading B cells down the right path

Nature Structural & Molecular Biology volume 18, pages 13171321 (2011) | Download Citation

Until recently, few potent and broadly neutralizing HIV-specific antibodies had been identified, but recent findings have inspired optimism that an effective HIV vaccine can finally be developed. Here we review these studies, which used state-of-the-art high-throughput techniques to collectively describe hundreds of new potent and broad HIV-neutralizing antibodies isolated from HIV-infected individuals.

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References

  1. 1.

    & N. Engl. J. Med. 365, 873–875 (2011).

  2. 2.

    & Immunity 33, 542–554 (2010).

  3. 3.

    et al. N. Engl. J. Med. 361, 2209–2220 (2009).

  4. 4.

    Science 333, 1560 (2011).

  5. 5.

    et al. Science 326, 285–289 (2009).

  6. 6.

    et al. Science 329, 856–861 (2010).

  7. 7.

    et al. Science 333, 1633–1637 (2011).

  8. 8.

    et al. Science 333, 1593–1602 (2011).

  9. 9.

    et al. Nature 477, 466–470 (2011).

  10. 10.

    , & Cold Spring Harb. Perspect. Biol. 3, a007278 (2011).

  11. 11.

    & Annu. Rev. Immunol. 24, 739–769 (2006).

  12. 12.

    et al. Science 329, 811–817 (2010).

  13. 13.

    et al. Science 301, 1374–1377 (2003).

  14. 14.

    et al. J. Exp. Med. 199, 145–150 (2004).

  15. 15.

    et al. Immunity 26, 205–213 (2007).

  16. 16.

    & Curr. Opin. Immunol. 20, 632–638 (2008).

  17. 17.

    et al. J. Exp. Med. 208, 181–193 (2011).

  18. 18.

    et al. Nature 467, 591–595 (2010).

  19. 19.

    et al. Nature 458, 636–640 (2009).

  20. 20.

    et al. Nature 445, 732–737 (2007).

  21. 21.

    et al. J. Virol. 85, 5262–5274 (2011).

  22. 22.

    & Nat. Rev. Immunol. 10, 527–535 (2010).

  23. 23.

    et al. J. Virol. 85, 9887–9898 (2011).

  24. 24.

    et al. Science published online, doi:0.1126/science.1213256 (13 October 2011).

  25. 25.

    & Annu. Rev. Immunol. 28, 413–444 (2010).

  26. 26.

    & Curr. Opin. Immunol. 22, 358–366 (2010).

  27. 27.

    , , & Science published online doi:10.1126/science.1213782 (27 October 2011).

  28. 28.

    , & Curr. Opin. HIV AIDS 4, 358–363 (2009).

  29. 29.

    , & J. Autoimmun. 29, 219–228 (2007).

  30. 30.

    et al. Science 308, 1906–1908 (2005).

  31. 31.

    , & Cell Host & Microbe 6, 292–294 (2009).

Download references

Acknowledgements

This work was funded by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, US National Institutes of Health.

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Affiliations

  1. Susan Moir and Anthony S. Fauci are in the Laboratory of Immunoregulation, US National Institutes of Health, Bethesda, Maryland, USA.

    • Susan Moir
    •  & Anthony S Fauci
  2. Angela Malaspina is in the Division of AIDS at the National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.

    • Angela Malaspina

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Susan Moir or Anthony S Fauci.

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DOI

https://doi.org/10.1038/nsmb.2194

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