New structures of SH3 domains complexed with proline-rich peptides show that the ligands can bind in two opposite orientations; this feature has not been seen before in protein/protein recognition.
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References
Terasawa, H. et al. Nature struct. Biol., 891–897 (1994).
Goudreau, N. et al. Nature Struct. Biol., 898–907 (1994).
Lim, W.A., Richards, F.M. & Fox, R.O. Nature, in the press.
Wittekind, M. et al. Biochemistry, in press.
Yu, H. et al. Cell 76, 933–945 (1994).
Musacchio, A., Saraste, M. & Wilmanns, M., Nature struct. Biol. 1, 546–551 (1994).
Cicchetti, P., Mayer, B.J., Thiel, G. & Baltimore,D. Science 257, 803–806 (1992).
Ren, R., Mayer, B.J., Cicchetti, P. & Baltimore,D. Science 259, 1157–1161 (1993).
Adzhubei, A.A., & Sternberg, M.J.E. J. molec. Biol. 229, 472–493 (1993).
Stern, L.J. et al. Nature 368, 215–221 (1994).
Williamson, M.P. Biochem. J. 297, 249–260 (1994).
Musacchio, A., Gibson, T., Lehto, V.-P. & Saraste, M. FEBS Lett. 307, 55–61 (1992).
Musacchio, A., Wilmanns, M. & Saraste, M. Prog. Biophys. molec Biol. 61, 283–297 (1994).
Musacchio, A., Noble, M., Pauptit, R., Wierenga, R. & Saraste, M. Nature 359, 851–854 (1992).
Cowburn, D. Nature struct. Biol. 1, 489–491 (1994).
Downward, J. FEBS Lett. 338, 113–117 (1994).
Pawson, T. & Schlessinger, J., Curr. Biol. 3, 434–442 (1993).
Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T. & Bowtell, D. Nature 363, 83–85 (1993).
Cussac, D., Frech, M. & Chardin, P. EMBO J. 13, 4011–4021 (1994).
Lim, W.A., Fox, R.O. & Richards, F. Prot. Sci. 3, 1261–1266 (1994).
Pisabarro, M.T., Ortiz, A.R., Viguera, A.R., Gago, F. & Serrano, L. Prot. Eng., in the press.
Lim, W.A.. & Richards, F.M. Nature struct. Biol. 1, 221–225 (1994).
Viguera, A.R., Arrondo, J.L., Musacchio, A., Saraste, M. & Serrano, L. Biochemistry 33, 10925–10933 (1994).
Gout, I. et al. Cell 75, 25–36 (1993).
Nicholls, A., Sharp, K.A. & Honig, B. Prot.Struct. Funct. Genet. 11, 281–293 (1991).
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Saraste, M., Musacchio, A. Backwards and forwards binding. Nat Struct Mol Biol 1, 835–837 (1994). https://doi.org/10.1038/nsb1294-835
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DOI: https://doi.org/10.1038/nsb1294-835
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