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Will any dimer do?

Nature Structural Biology volume 5, pages 938–940 (1998)Cite this article

Abstract

New structural information on the interaction of erythropoietin with its receptor suggests that the orientation of receptor dimers is critical to intracellular activation.

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Figure 1: Schematic showing relative orientations of EPO receptor extracellular chains when complexed with EPO1, EMP13, and EMP332.
Figure 2: EPOR complexes capable of signal transduction.

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Acknowledgements

The authors thank R. Stroud for helpful discussions and M. Randal for assistance with graphics.

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  1. Sunesis Pharmaceuticals, Inc., 3696 Haven Avenue Suite C,, Redwood City, 94063, California, USA

    Marcus D. Ballinger & James A. Wells

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  1. Marcus D. Ballinger
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  2. James A. Wells
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Ballinger, M., Wells, J. Will any dimer do?. Nat Struct Mol Biol 5, 938–940 (1998). https://doi.org/10.1038/2911

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