C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DMA at promoters or origins of replication.

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Brandsen, J., Werten, S., van der Vliet, P. et al. C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. Nat Struct Mol Biol 4, 900–903 (1997). https://doi.org/10.1038/nsb1197-900

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