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A novel RNA-binding motif in influenza A virus non-structural protein 1

Nature Structural Biology volume 4, pages 891–895 (1997)Cite this article

The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2′ forms a novel arginine-rich nucleic acid binding motif.

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Authors and Affiliations

  1. Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, 08854-5638, USA

    Chen-ya Chien, Roberto Tejero, Yuanpeng Huang, Diane E. Zimmerman, Carlos B. Ríos & Gaetano T. Montelione

  2. Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, 08854-5638, USA

    Chen-ya Chien, Diane E. Zimmerman, Carlos B. Ríos, Robert M. Krug & Gaetano T. Montelione

  3. Departamento de Quimica Fisica, Universidad de Valencia, Dr. Moliner 50, 46100, Burjassot (Valencia), Spain

    Roberto Tejero

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Chien, Cy., Tejero, R., Huang, Y. et al. A novel RNA-binding motif in influenza A virus non-structural protein 1. Nat Struct Mol Biol 4, 891–895 (1997). https://doi.org/10.1038/nsb1197-891

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