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The cyclooxygenase-2 stucture: new drugs for an old target?

Nature Structural Biology volume 3, pages 897901 (1996) | Download Citation

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The crystal structure of human cyclooxygenase-2 offers a unique opportunity for the design of new nonsteroidal anti-inflammatory drugs and may also provide insights into the mechanisms of membrane protein targeting and the role of prostaglandin physiology in inflammation and disease.

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Affiliations

  1. Department of Biochemistry Michigan State University East Lansing, Michigan 48824-1319, USA garavito@magaera.bch.msu.edu

    • R. Michael Garavito

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DOI

https://doi.org/10.1038/nsb1196-897

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